Health communication is widely considered to be a major aspect of any public health campaign. Strategies integrated into a community, based on personal contact and delivered through culturally appropriate media, are effective communication tools in Ghana. However, no comprehensive research has been conducted to analyze the success of public health campaigns that include extensive use of interpersonal communication. The goal of the research conducted was to discuss the impact of personal contact in the successofGhanaian public health initiatives. An analysis of four different public health campaigns in Ghana was performed, examining the communication strategies used in each. It was determined that using interpersonal communication, in conjunction with other appropriate strategies, gives the highest success rate in Ghanaian health campaigns.